Currax Pharmaceuticals to Spotlight New Research at ObesityWeek® 2025 Highlighting Craving Control, Behavioral Adherence, and Subpopulation Outcomes with CONTRAVE®
Data to be shared during an ObesityWeek press conference includes four of seven data presentations supporting CONTRAVE and its utility in helping people lose weight
BRENTWOOD, Tenn., Oct. 28, 2025 /PRNewswire/ — Currax Pharmaceuticals LLC (“Currax”), a pharmaceutical, company that delivers life-changing medicines to patients with chronic, progressive diseases, is set to present data at ObesityWeek® 2025, the annual meeting of The Obesity Society, being held Nov. 4-7 in Atlanta.
Currax is showcasing seven data presentations, including four selected for the official ObesityWeek press conference held Wednesday, Nov. 5, 2025. The new data highlights and underscores the differentiated profile of CONTRAVE® (naltrexone HCl/bupropion HCl) as an oral, non-GLP-1, combination therapy that helps adults manage weight by reducing appetite and supporting sustainable, long-term outcomes.
“During a period of significant advancement in obesity care, these studies examine the ways in which treatments such as CONTRAVE may expand current therapeutic options through greater understanding of both behavioral and biological determinants of weight management,” said Michael Kyle M.D., Chief Medical Officers of Currax Pharmaceuticals. “We continue to support the scientific community in expanding understanding of how evidence-based, accessible options can meet patients where they are on their journey toward improved health.”
ObesityWeek 2025 Poster Presentations
| Title: | Fixed-Dose, Extended-Release Combination of Naltrexone and Bupropion Reduces Craving and Body Weight |
| Presenter: | Dr. Robert F. Kushner, professor emeritus of endocrinology, metabolism and molecular medicine at Northwestern Feinberg School of Medicine |
| Date and time: | Nov. 4, 2025, 7:30-8:30 p.m. |
| Title: | Predictors of Response to Fixed-Dose, Extended-Release Combination of Naltrexone and Bupropion |
| Presenter: | Dr. Donna Ryan, Associate Executive Director for Clinical Research at Pennington Biomedical Research Center |
| Date and time: | Nov. 4, 2025, 7:30-8:30 p.m. |
| Title: | Fixed-Dose, Extended-Release Combination of Naltrexone and Bupropion Reduces Body Weight and Smoking |
| Presenter: | Dr. Christopher Still, Director of Nutrition and Weight Management, Geisinger Medical Center |
| Date and time: | Nov. 6, 2025, 2:30-3:30 p.m. |
| Title: | Use of Naltrexone-Bupropion in Persons with Overweight/Obesity and Symptoms of Depression |
| Presenter: | Dr. Caroline M Apovian, Co-Director, Center for Weight Management and Wellness, Brigham and Women’s Hospital |
| Date and time: | Nov. 4, 2025, 7:30-8:30 p.m. |
Additional ObesityWeek 2025 Presentations
| Title: | Weight Loss With Naltrexone-Bupropion Is Associated with Depression and Anxiety in Obesity |
| Presenter: | Dr. Jose Villamarin, post-doctoral Research Fellow Gastroenterology and Hepatology, Mayo Clinic |
| Date and time: | Nov. 4, 2025, 1:45-2:00 p.m. |
| Room: | A311-A312 |
| Title: | Analyzing Changes in Diet Quality and Caloric Intake for Patients Taking Naltrexone/Bupropion |
| Presenter: | Dr. Jeffrey Alfonsi MD, FRCPC, Dipl ABOM & ABLM, Chief Medical Officer of RxFood |
| Date and time: | Nov. 4, 2025, 7:30-8:30 p.m. |
| Title: | Potential Obesity Cost Savings Resulting from Naltrexone-Bupropion Treatment: a US Real-World Survey |
| Presenter: | David Savastano, Ph.D., Senior Director, Medical Affairs, Currax |
| Date and time: | Nov. 4, 2025, 7:30-8:30 p.m. |
About Currax
Currax is a specialty pharmaceutical company that pursues transformative therapies for chronic conditions like obesity. Combining innovative advancements with compassionate care, Currax delivers therapies that are designed to inspire hope and offer life-changing outcomes. Currax’s flagship product, CONTRAVE® (naltrexone HCl/bupropion HCl), reflects the company’s commitment to provide therapies that offer unmatched versatility and utility. Learn more at www.curraxpharma.com
About CONTRAVE:
CONTRAVE®, is an extended-release fixed dose combination of naltrexone and bupropion (naltrexone HCl/bupropion HCl) indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index (BMI) of 30 kg/m2 or greater (obese), or adults with a BMI of 27 kg/m2 or greater (overweight) with at least one weight-related medical problem such as high blood pressure, high cholesterol, or type 2 diabetes. For full Prescribing Information, including BOXED WARNING and Medication Guide, please visit www.contrave.com.
What is CONTRAVE?
CONTRAVE is a prescription weight-loss medicine that may help some adults with a body mass index (BMI) of 30 kg/m2 or greater (obese), or adults with a BMI of 27 kg/m2 or greater (overweight) with at least one weight-related medical problem such as high blood pressure, high cholesterol, or type 2 diabetes, lose weight and keep the weight off.
CONTRAVE should be used with a reduced-calorie diet and increased physical activity.
It is not known if CONTRAVE changes your risk of heart problems or stroke or of death due to heart problems or stroke.
It is not known if CONTRAVE is safe and effective when taken with other prescription, over-the-counter, or herbal weight-loss products.
CONTRAVE is not approved to treat depression or other mental illnesses, or to help people quit smoking (smoking cessation).
Please see Full Prescribing Information , including Medication Guide , for CONTRAVE.
IMPORTANT SAFTEY INFORMATION
CONTRAVE can cause serious side effects including:
Suicidal thoughts or actions: One of the ingredients in CONTRAVE is bupropion. Bupropion has caused some people to have suicidal thoughts or actions or unusual changes in behavior, whether or not they are taking medicines used to treat depression. Bupropion may increase the risk of suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment. If you already have depression or other mental illnesses, taking bupropion may cause it to get worse, especially within the first few months of treatment.
While taking CONTRAVE, you or your family members should pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. This is very important when you start taking CONTRAVE or when your dose changes.
Stop taking CONTRAVE and call a healthcare provider right away if you or your family members notice any of the following symptoms, especially if they are new, worse, or worry you: thoughts about suicide or dying; attempts to commit suicide; depression; anxiety; feeling agitated or restless; panic attacks; irritability; aggression, anger, or violence; acting on dangerous impulses; an extreme increase in activity and talking; other unusual changes in behavior or mood; trouble sleeping.
CONTRAVE is not approved for use in children under the age of 18.
Do not take CONTRAVE if you have uncontrolled high blood pressure; have or have had seizures; use other medicines that contain bupropion such as WELLBUTRIN, WELLBUTRIN SR, WELLBUTRIN XL, APLENZIN and ZYBAN; have or have had an eating disorder called anorexia or bulimia; are dependent on opioid pain medicines or use medicines to help stop taking opioids, or are in opiate withdrawal; drink a lot of alcohol and abruptly stop drinking, or use medicines called sedatives (these make you sleepy), benzodiazepines, or anti‐seizure medicines and stop using them all of a sudden; are taking or have taken medicines called monoamine oxidase inhibitors (MAOIs) in the past 14 days; or are allergic to any of the ingredients in CONTRAVE.
Tell your healthcare provider about all of your medical conditions, including if you have: depression or other mental illnesses; attempted suicide; seizures; head injury; tumor or infection of brain or spine; low blood sugar or low sodium; liver or kidney problems; high blood pressure; heart attack, heart problems, or stroke; eating disorder; drinking a lot of alcohol; prescription medicine or street drug abuse; are 65 or older; diabetes; pregnant or planning to become pregnant; or breastfeeding.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
CONTRAVE may cause serious side effects, including:
- Seizures. There is a risk of having a seizure when you take CONTRAVE. The risk of seizure is higher in people who take higher doses of CONTRAVE, have certain medical conditions, or take CONTRAVE with certain other medicines. Do not take any other medicines while you are taking CONTRAVE unless your healthcare provider has said it is okay to take them. If you have a seizure while taking CONTRAVE, stop taking CONTRAVE and call your healthcare provider right away.
- Risk of opioid overdose. Do not take large amounts of opioids, including opioid-containing medicines, such as heroin or prescription pain pills, to try to overcome the opioid-blocking effects of naltrexone. This can lead to serious injury, coma, or death.
Get emergency medical help right away if you take opioids and you:- have trouble breathing
- become very drowsy with slowed breathing
- have slow, shallow breathing
- feel faint, very dizzy, confused, or have unusual symptoms
- Sudden opioid withdrawal. People who take CONTRAVE must not use any type of opioid, including street drugs, prescription pain medicines, cough, cold, or diarrhea medicines that contain opioids, or opioid dependence treatments, for at least 7 to 10 days before starting CONTRAVE. Using opioids in the 7 to 10 days before you start taking CONTRAVE may cause you to suddenly have symptoms of opioid withdrawal when you take it. Sudden opioid withdrawal can be severe, and you may need to go to the hospital. Tell your healthcare provider you are taking CONTRAVE before a medical procedure or surgery.
- Severe allergic reactions. Stop taking CONTRAVE and call your healthcare provider or go to the nearest hospital emergency room right away if you have any of the following signs and symptoms of an allergic reaction: rash, itching, hives, fever, swollen lymph glands, painful sores in your mouth or around your eyes, swelling of your lips or tongue, chest pain, or trouble breathing.
- Increases in blood pressure or heart rate. Some people may get high blood pressure or have a higher heart rate when taking CONTRAVE. Your healthcare provider should check your blood pressure and heart rate before you start taking, and while you take CONTRAVE.
- Liver damage or hepatitis. Stop taking CONTRAVE and tell your healthcare provider if you have any of the following symptoms of liver problems: stomach area pain lasting more than a few days, dark urine, yellowing of the whites of your eyes, or tiredness. Your healthcare provider may need to stop treating you with CONTRAVE if you get signs or symptoms of a serious liver problem.
- Manic episodes. Bupropion can cause some people who were manic or depressed in the past to become manic or depressed again.
- Visual problems (angle-closure glaucoma). Signs and symptoms may include: eye pain, changes in vision, swelling or redness in or around the eye. Talk with your healthcare provider to find out if you are at risk for angle‐closure glaucoma and to get treatment to prevent it if you are at risk.
- Increased risk of low blood sugar in people with type 2 diabetes mellitus who also take medicines to treat their diabetes (such as insulin or sulfonylureas). You should check your blood sugar before you start taking CONTRAVE and while you take CONTRAVE.
The most common side effects of CONTRAVE include nausea, constipation, headache, vomiting, dizziness, trouble sleeping, dry mouth, and diarrhea. These are not all of the possible side effects of CONTRAVE.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088 .
Media Contact
[email protected]